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by P Svensson - 2007 - Cited by 8 - Related articlesThe motor programs related to such different types of jaw-movements could also be differentially influenced by pain. Nevertheless, the HEP models and animal
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by JS Church - Cited by 1 - Related articlesA whole-animal alternative model for pain research. Animal-Welf-. Inf-Cent-news v. 8 (3/4) p. 3-5. Thompson, S. E. and J. M. Johnson (1991).
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Aug 26, 2008 There were 37 presentations at the World Congress on Pain that describe animal pain models, including models of complex regional pain
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by SK Joshi - 2006 - Cited by 4 - Related articlesAlthough these animal models have helped to better understand pain physio- pharmacology mechanisms, one should remember that even for patients labelled under
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.chronic orofacial pain in an animal model. Current measures of pain in animal models do not accurately reflect human chronic pain disorders because the
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Pain and distress caused by specific research models and techniques raise serious concerns for those in the animal welfare community as well as in the
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by AE Olesen - 2009 - Cited by 1 - Related articlesJan 14, 2009 These pain models facilitate minimizing the gap between knowledge gained in animal and human clinical studies. Combining
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.How to study mechanisms of neuropathic pain. Antti Pertovaara, Institute of Biomedicine, University of Helsinki. Animal models of pain, Video demonstrations
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.transmission and modulation of nociceptive signals and pain has been gained by studies in animals. ✍ Early studies used primarily acute pain models and
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by V Awards - 2005 - Related articlesMar 28, 2005 Suturing the sciatic nerve creates a chronic pain model of peripheral nerve injury. "Often within a week, animals begin to show a number of
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The role of endogenous opioid-ergic analgesia systems has been also demonstrated by Mantyh's group, in another animal cancer pain model, wherein genetically
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by JINH OH - 2006 - Cited by 5 - Related articlesIn the present study, the pain relieving effect of acupuncture and electroacupuncture was examined using an animal arthritic pain model.
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Your browser may not have a PDF reader available. Google recommends visiting our text version of this document.that the mouse model of incision-induced pain could be a reliable, useful tool to investigate differ from that of other animal pain models,10,11,19,20
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Animal models that proximate human neuropathic pain allow the molecular and cellular events underlying abnormal sensory processing and disproportionate pain
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by LM Batista - 2009 - Related articlesKEY WORDS: pain, postoperative, sciatic neuropathy, analgesia, lidocaine, experimental animal models. Efeito analgésico preemptivo da lidocaína em modelo de
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by S Abdi - 2000 - Cited by 4 - Related articlesWe studied the effects of a spicamycin derivative, KRN5500, on two animal models of neuropathic pain (Chung and Bennett models) and a nociceptive pain model
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Taken together, the animal models combined with peptidomic approaches will serve as an instrument to identify pain-related biomarkers to be screened in
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by JW Leiphart - 2009 - Related articlesOct 9, 2009 Studies of pain in animal models present a different picture. In a rat model of postoperative pain, weight loss was mitigated by effective
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by P Chandran - 2008The present invention presents a novel activity-induced pain behavior in ostoeoarthritic animals, useful for pharmacological characterization of potential
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.Nov 17, 2004 k. Euthanasia followed by tissue collection l. Pain models in which animals can compensate for any potential pain by behavioral modification
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Clinically, inflammatory pain is far more persistent than that typically modelled pre-clinically, with the majority of animal models focussing on short- term
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Your browser may not have a PDF reader available. Google recommends visiting our text version of this document.by N Inoue - 2009 - Related articlesneuropathic pain patients and animal models. In the present study, .. Etodolac in a Neuropathic Pain Model. 605. 4 Hogan Q. Animal pain models.
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by X Wang - 2006 - Cited by 20 - Related articlesFeb 23, 2006 Persistent pain model reveals sex difference in morphine potency . Study of Pain; all protocols were approved by the Institutional Animal
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File Format: PDF/Adobe AcrobatYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by KE Lee - Cited by 28 - Related articlesbehavioral hypersensitivities after joint injury. In previous studies using animal models of low back pain, mechanical allodynia has been correlated with
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by GT Whiteside - 2008 - Cited by 10 - Related articlesWhile a number of reports cite failures of animal pain models to predict efficacy in humans, few have actually analyzed where these models have been
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This paper shows that selective activation of subtype-specific GABA-A receptors is effective in both neuropathic and inflammatory pain in animal models,
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by LX Wang - 2003 - Cited by 47 - Related articlesrelevant animal models to study these painful con- totomy (see below) have been suggested as indica- ditions. Most neuropathic pain models are made by
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by H SEKIYAMA - 2006Abstract;New animal models of pain were described. 1) A model of neurogenic pain and afterwards, 2) postherpetic neuralgia model, 3) the diabetic neurogenic
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by R Zuzana - 2006While a number of reports cite failures of animal pain models to predict efficacy in Finally we discuss where and why animal pain models have failed and
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by SD Shields - 2003 - Cited by 38 - Related articles[13, 19 and 23] The development of animal models of nerve injury–induced pain has contributed significantly to the analysis of mechanisms that contribute to
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by M Eaton - 2003 - Cited by 18 - Related articlesAbstract—Animal models of spasticity and pain have allowed for the elucidation of possible .. variety of animal models for pain would be to separate
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Table A-1 presents commonly used models of persistent pain in animals and the Animal models of momen- tary pain are fully described in a comprehensive
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by using these methods after local or systemic administration in normal animals and in acute, chronic, and neuropathic pain models mentioned above.
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Accordingly, all issues of animal pain and distress, and their potential . Studies on induced animal models of human diseases. Here, an animal is treated
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by FJ van der Staay - 2009 - Cited by 3 - Related articlesWhiteside GT, Adedoyin A, Leventhal L: Predictive validity of animal pain models ? A comparison of the pharmacokinetic-pharnacodynamic relationship for pain
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differences between animals and humans, animal pain models also have the disadvantage that the interpretation of pain usually relies on the observation of
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Oct 28, 2009 Animal pain models are used in laboratory studies in companion animals (dogs, cats and horses) to test the effectiveness of various
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by KI Vadakkan - 2005 - Cited by 17 - Related articlesDifferent laboratory animal models of neuropathic pain that replicate pathophysiological changes in patients have been developed. In most animal models of
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Evaluation of selective NK1 receptor antagonist CI-1021 in animal models of inflammatory and neuropathic pain. J. Pharmacol. Exp. Ther. 294:444-450.
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That's the underlying issue (other than the innate cruelty of causing pain in unwilling subjects) — despite our similarities, animal models really don't
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differences between animals and humans, animal pain models also have the disadvantage In a separate animal pain model (also a part of the same set of
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Many are frustrated with the lack of translational progress in the pain field, in which huge gains in basic science knowledge obtained using animal models
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by JS Mogil - 2009 - Cited by 20 - Related articlesWhiteside, G. T., Adedoyin, A. & Leventhal, L. Predictive validity of animal pain models? A comparison of the pharmacokinetic-pharmacodynamic relationship
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Areas for improvement include further refinement of animal pain models to improve their ability to successfully predict efficacy in clinical trials in
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Jump to Pain: Most pain models can be performed in both rats and mice. Incapacitance meter to assess the guarding response in animals with an
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by M Nishiyori - 2008 - Cited by 5 - Related articlesIn a new mouse model for generalized pain syndrome, including fibromyalgia, which used intermittent cold stress (ICS), bilateral allodynia in the hindpaw
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May 2, 2009 Translating nociceptive processing into human pain models. . ABC story on FDA Acetaminophen overdose report · Pain in animal slaughter
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Xie is a professor in physiology, Medical School of Peking Union Medical College , and a pioneer in pain animal model. With more than 30 years research in
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Animal models of pain can be generally classified as either somatic pain Models of acute pain measure the behavioural responses of naive animals to
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Mar 25, 2010 Using a novel animal model to study craniofacial pain, researchers have discovered that when tissues are inflamed, the nerve cells carrying
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Apr 17, 2010 10:50 Human experimental pain models in early drug development. • Translation from animal to human pain models.
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by R Succar - 2007 - Cited by 11 - Related articlesAnimal studies have shown that NA-glycine produces analgesia in acute pain models, reduces the allodynia associated with nerve ligation induced neuropathic
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by LS Sorkin - 2001 - Cited by 28 - Related articlesWe wished to examine the effects of spinal JST in other mechanistically distinct models of nociception to see if animal models of pain that are sensitive to
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Mar 25, 2010 Using a novel animal model to study craniofacial pain, researchers at Oregon Health & Science University's School of Dentistry
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by S MULTON - 2005 - Cited by 16 - Related articlesVNS (NCP-Cyberonics®) in animal pain models : personal contribution. Before specifically applying VNS in the treat- ment of refractory pain, its efficiency
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by D Le Bars - 2001 - Cited by 343 - Related articlesThere are also animal models of visceral pain triggered by mechanical stimuli, It cannot be stated often enough that in most animal models of pain,
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by D Sapunar - 2009However, much ethodological diversity exists and different interpretations of behavioral tests are used to assess pain in animal models.
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by DW Han - 2006 - Cited by 7 - Related articlesAn animal model of neuropathic pain employing injury to the sciatic nerve branches. Neuroreport 2000;11:657-61. 4. Baron R, Janig W, Kollmann W. Sympathetic
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Jan 11, 2010 Download A new animal model of Post-Operative Pain Whitepaper An optimal model for assesssment of analgesic effect of various local
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by DA Fishbain - 2000 - Cited by 57 - Related articlesThe animal and human studies were then sorted according to the pain model represented, e.g., neuropathic pain model. Studies were then characterized
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Mathews NS: A review of equine pain models. In: Animal Pain eds: Short CE, Van Poznak A. Churchill Livingstone, NewYork, 1992. What causes pain in the horse
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Oct 26, 2009 The contractor shall also include hands-on training in animal surgeries and chemical- and disease-induced neuropathic pain models,
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Animal models of Ocular Pain: Iris Pharma develops new animal models of Ocular Pain. Iris Pharma improves the existing animal models of Ocular Pain.
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Mar 27, 2010 Using a novel animal model to study craniofacial pain, researchers at Oregon Health & Science University's School of Dentistry have
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In a separate animal pain model (also a part of the same set of experiments described above), decursinol was found to attenuate the number of writhings
Aug 4, 2007 The role of the 2 adrenergic system in neuropathic pain has been studied using various pharmacologic interventions and animal models.63 In
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To facilitate the study of pain transmission and the characterization of novel analgesic compounds, an array of experimental animal pain models has been
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Your browser may not have a PDF reader available. Google recommends visiting our text version of this document.by KJ Kim - 1997 - Cited by 187 - Related articlesComparison of three rodent neuropathic pain models. Received: 13 June 1996/ Accepted: 8 August 1996. Abstract To characterize various animal models of neu-
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by A Mukherjee - 2009 - Related articlesPain is an unpleasant sensation localized to a part of the action of Phlogacanthus thyrsiflorus in experimental animal models. The extract
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Refined ex-vivo rodent heart model reduces in vivo experimentation. Detection of Pain in Laboratory Animals via Gene Expression?
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by D Le Bars - 2001 - Cited by 8 - Related articlesObjective: To analyse models of acute pain in experimental animals.Data sources: References were obtained from computerised bibliographic data banks
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Aug 14, 2008 Alan Silman, medical director of the Arthritis Research Campaign, agreed that animals were not good models of pain in humans.
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File Format: PDF/Adobe Acrobat - Quick ViewYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.A. Know criteria that define useful and ethical animal models of pain. . Pain 1983; 16:109–110. Le Bars D, Gozariu M, Cadden SW. Animal models of
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Animal Models of Pain - With the loss of work days, the price of health care and payments for compensation, litigation, and malpractice,
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Interleukin-1 (IL-1) may be a principal mediator of pain and inflammation in gout and pseudogout, and its release may be triggered by monosodium urate and
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Accordingly, these animal models of pain have become standards in the screening of putative analgesics. Ethically, these models are not generally
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10:50 Human experimental pain models in early drug development • Translation from animal to human pain models • Back-translation from human models to animal
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Jun 1, 2010 Oct 12, 2006 Members of the Clinical Pain Research Program include: evolution of animal models of nociceptive processing (hyperalgesia,
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Amphibian models of nociception and pain. In Animal Models of Nociception and Pain, Kavaliers, M. K., Ossenkopp, K. P., and P. R. Sanberg (eds.
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May 25, 2010 Related Blogs on animal pain relief: Controversial Treatments Like . VNS (NCP -Cyberonics®) in animal pain models : personal contribution.
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by I Decosterd - 2004 - Cited by 33 - Related articlesAnimal neuropathic pain models have been designed to mimic the pain symptoms encountered in humans. Injection of chemicals, nerve transection,
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File Format: PDF/Adobe AcrobatYour browser may not have a PDF reader available. Google recommends visiting our text version of this document.by KR Paudel - Related articlesantinociceptive effect of amitriptyline in acute pain models of mice through Hot -Plate and Tail-Flick tests. Materials and Methods. Animals- Experiments